Synthesis and Anti-HBV Activity of Novel Substituted Pyrimidine Glycosides and Their Acyclic Analogues
- Authors: Hawata M.A.1, El-Sayed W.A.2, Abdel-Rahman A.A.1
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Affiliations:
- Chemistry Department, Faculty of Science
- Photochemistry Department
- Issue: Vol 88, No 8 (2018)
- Pages: 1734-1744
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222383
- DOI: https://doi.org/10.1134/S1070363218080285
- ID: 222383
Cite item
Abstract
New aryl substituted uracil and thiouracil glycosides are synthesized by glycosylation at N1 in the pyrimidine nucleus using glycopyranosyl halides in basic medium. In addition C-linked hydrazinyl acyclic sugar derivatives exhibiting different sugar moieties, attached at C6, are also prepared. Antiviral activity of the newly synthesized compounds is studied against Hepatitis B virus (HBV). The antiviral tests data indicated high activity of compounds 6b, 6c and 12a–12c with mild cytotoxic effects. The influence of glycosyl moieties attached to the substituted pyrimidine system in addition to the substitution at the aryl fragment on activity is discussed.
Keywords
About the authors
M. A. Hawata
Chemistry Department, Faculty of Science
Email: waelshendy@gmail.com
Egypt, Shebin El-Kom, 32511
W. A. El-Sayed
Photochemistry Department
Author for correspondence.
Email: waelshendy@gmail.com
Egypt, Dokki, Cairo, 12622
Adel A.-H. Abdel-Rahman
Chemistry Department, Faculty of Science
Email: waelshendy@gmail.com
Egypt, Shebin El-Kom, 32511
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