Synthesis and Biological Activity of Mono- and Dibromo Derivatives of 2-Amino-5-(2-aryl-2-oxoethylidene)-4-oxo-1 H -4,5-dihydrofuran-3-carboxylic Acids

M. V. Dmitriev; D. V. Ivanov; N. M. Igidov; R. R. Makhmudov; V. V. Novikova; I. N. Chernov

doi:10.1134/S1070363218070083

Synthesis and Biological Activity of Mono- and Dibromo Derivatives of 2-Amino-5-(2-aryl-2-oxoethylidene)-4-oxo-1H-4,5-dihydrofuran-3-carboxylic Acids

Authors: Dmitriev M.V.¹, Ivanov D.V.¹^,2, Igidov N.M.², Makhmudov R.R.¹, Novikova V.V.², Chernov I.N.³
Affiliations:
1. Perm State National Research University
2. Perm State Pharmaceutical Academy
3. Research Institute for Chemistry
Issue: Vol 88, No 7 (2018)
Pages: 1397-1401
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222309
DOI: https://doi.org/10.1134/S1070363218070083
ID: 222309

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Abstract

The previously unknown mono- and dibromo derivatives of 2-amino-5-(2-aryl-2-oxo-ethylidene)-4-oxo-1H-4,5-dihydrofuran-3-carboxylic acids were synthesized. Antinociceptive and antimicrobial activity of the obtained compounds was studied.