Microwave Assisted, Solvent-Free, “Green” Synthesis of Novel Indole Analogs as Potent Antitubercular and Antimicrobial Agents and Their Molecular Docking Studies
- Authors: Rathod A.S.1, Godipurge S.S.1, Biradar J.S.1
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Affiliations:
- Central Research Laboratory, Department of Chemistry
- Issue: Vol 88, No 6 (2018)
- Pages: 1238-1246
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222270
- DOI: https://doi.org/10.1134/S1070363218060324
- ID: 222270
Cite item
Abstract
A rapid, efficient and environmentally benign synthesis of novel indole analogs bearing thiazolidinone attached to substituted thiazolyl coumarin scaffolds are synthesized. Conventional and microwave-assisted (MW) approaches are studied. Structures of the products are confirmed by FT-IR, NMR (1H and 13C) and Mass spectra. The in vitro antitubercular and antimicrobial activities are evaluated. Several screened compounds demonstrate promising anti-TB and antimicrobial properties. The structure activity relationship (SAR) study reveal that the compounds containing halogens are most potent. Docking of the potent compounds inside the active site of a target enzyme mycobacterial enoyl reductase (InhA)(PDB code 4TZK) is performed.
About the authors
A. S. Rathod
Central Research Laboratory, Department of Chemistry
Author for correspondence.
Email: anilrathod086@gmail.com
India, Kalaburagi, Karnataka, 585106
S. S. Godipurge
Central Research Laboratory, Department of Chemistry
Email: anilrathod086@gmail.com
India, Kalaburagi, Karnataka, 585106
J. S. Biradar
Central Research Laboratory, Department of Chemistry
Email: anilrathod086@gmail.com
India, Kalaburagi, Karnataka, 585106
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