Synthesis of 5-Aryl-4-aroyl-3-hydroxy-1-cyanomethyl-3-pyrrolin-2-ones

V. L. Gein; E. A. Buldakova; A. N. Korol; G. A. Veikhman; M. V. Dmitriev

doi:10.1134/S1070363218050110

Synthesis of 5-Aryl-4-aroyl-3-hydroxy-1-cyanomethyl-3-pyrrolin-2-ones

Authors: Gein V.L.¹, Buldakova E.A.¹, Korol A.N.¹, Veikhman G.A.¹, Dmitriev M.V.²
Affiliations:
1. Perm State Pharmaceutical Academy
2. Perm State National Research University
Issue: Vol 88, No 5 (2018)
Pages: 908-911
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222179
DOI: https://doi.org/10.1134/S1070363218050110
ID: 222179

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Abstract

5-Aryl-4-aroyl-3-hydroxy-1-cyanomethyl-3-pyrrolin-2-ones were synthesized by a three-component reaction of methyl aroylpyruvate with a mixture of aromatic aldehyde and 2-aminoacetonitrile sulfate in glacial acetic acid in the presence of anhydrous sodium acetate.