Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel 1,2,3-Triazole Tagged 5-[(1H-Indol-3-yl)methylene]pyrimidine-2,4,6(1H,3H,5H)trione Derivatives


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详细

Novel 5-{(1-[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]-1H-indol-3-yl)methylene}pyrimidine-2,4,6-(1H,3H,5H)trione derivatives (5a5k) were synthesized by the click reaction. All compounds 5a5k were characterized by 1H and 13C NMR, IR and Mass spectra and evaluated for their in vitro anticancer activity against cervical cancer cell lines. Among all, compound 5e (IC50 = 6.76 μM), shown high inhibitory activity. Docking analysis of all the compounds with the Lipid kinase PI3K-α revealed that the compound 5e fitted well in the active site pocket, showing the best docking score (LibDock) of 123.274.

作者简介

Ashok Kumar

Department of Chemistry; Department of Chemistry

编辑信件的主要联系方式.
Email: mailme2ashokkumar@gmail.com
印度, Yamnampet, Ghatkesar, Hyderabad, Telangana, 501301; Green Fields, Vaddeswaram, Guntur (Dist), Andhra Pradesh, 522502

B. Sathish Kumar

Department of Chemistry

Email: mailme2ashokkumar@gmail.com
印度, Hyderabad, Telangana, 500007

E. Sreenivas

Bioinformatics Division

Email: mailme2ashokkumar@gmail.com
印度, Nallakunta, Hyderabad, Telangana, 500044

T. Subbaiah

Department of Chemistry

Email: mailme2ashokkumar@gmail.com
印度, Green Fields, Vaddeswaram, Guntur (Dist), Andhra Pradesh, 522502

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