Synthesis of Fluorine-Containing Derivatives of 5-Arylisoxazoles and 4,5-Dichlorothiazole
- Authors: Petkevich S.K.1, Dikusar E.A.1, Kletskov A.V.1, Rozenzveig I.B.2, Levkovskaya G.G.2, Kurman P.V.3, Zolotar’ R.M.3, Potkin V.I.1
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Affiliations:
- Institute of Physical Organic Chemistry
- Favorskii Irkutsk Institute of Chemistry, Siberian Branch
- Institute of Bioorganic Chemistry
- Issue: Vol 88, No 2 (2018)
- Pages: 234-240
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221990
- DOI: https://doi.org/10.1134/S1070363218020081
- ID: 221990
Cite item
Abstract
Alkylation of fluorophenols and phenolic aldehydes with 5-phenyl(p-tolyl)-3-chloromethylisoxazole under the Williamson reaction conditions afforded the corresponding ethers. Condensation of the resulting phenolic aldehyde derivatives and 5-phenyl(p-tolyl)isoxazole-3-carbaldehydes with p-fluoroaniline resulted in fluorine-containing azomethines. Acylation of fluorinated amines with 5-(p-tolyl)isoxazole- and 4,5- dichloroisothiazole-3-carbonyl chlorides gave rise to fluorinated amides bearing isoxazole and isothiazole fragments, representatives of which showed a synergistic effect in compositions with insecticides.
Keywords
About the authors
S. K. Petkevich
Institute of Physical Organic Chemistry
Author for correspondence.
Email: petkevich@ifoch.bas-net.by
Belarus, ul. Surganova 13, Minsk, 220072
E. A. Dikusar
Institute of Physical Organic Chemistry
Email: petkevich@ifoch.bas-net.by
Belarus, ul. Surganova 13, Minsk, 220072
A. V. Kletskov
Institute of Physical Organic Chemistry
Email: petkevich@ifoch.bas-net.by
Belarus, ul. Surganova 13, Minsk, 220072
I. B. Rozenzveig
Favorskii Irkutsk Institute of Chemistry, Siberian Branch
Email: petkevich@ifoch.bas-net.by
Russian Federation, Irkutsk
G. G. Levkovskaya
Favorskii Irkutsk Institute of Chemistry, Siberian Branch
Email: petkevich@ifoch.bas-net.by
Russian Federation, Irkutsk
P. V. Kurman
Institute of Bioorganic Chemistry
Email: petkevich@ifoch.bas-net.by
Belarus, Minsk
R. M. Zolotar’
Institute of Bioorganic Chemistry
Email: petkevich@ifoch.bas-net.by
Belarus, Minsk
V. I. Potkin
Institute of Physical Organic Chemistry
Email: petkevich@ifoch.bas-net.by
Belarus, ul. Surganova 13, Minsk, 220072
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