Phosphonic Aminocarboxylic Acids
- Authors: Ragulin V.V.1
-
Affiliations:
- Institute of Physiologically Active Compounds
- Issue: Vol 88, No 2 (2018)
- Pages: 159-187
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221980
- DOI: https://doi.org/10.1134/S1070363218020019
- ID: 221980
Cite item
Abstract
Methods of synthesis of phosphonic aminocarboxylic acids, ω-phosphonic analogs of monoaminodicarboxylic acids, are reviewed. Many of such compounds are ligands of ionotropic and metabotropic glutamate receptors determining the phenomenon of information processing and communication in central nervous system, important in view of prevention and treatment of Alzheimer, Huntington, and Parkinson diseases and other socially important neurodegenerative and psychoneurological diseases as well as learning and memory processes.
About the authors
V. V. Ragulin
Institute of Physiologically Active Compounds
Author for correspondence.
Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432