Enantioselective Bioreduction of Acetophenone into (R)- and (S)-1-Phenylethanols

Abstract

The possibility of enantioselective bioreduction of acetophenone into (R)- and (S)-1-phenylethanol used in the synthesis of antifeedant, antidiabetic, antidepressant, antirabic, antiparasitic, antimicrobial, and antifungal agents is investigated. The influence of various exogenous reducing agents (isopropanol, ethanol, and glucose) on the yields of the target products and the enantioselectivity of the bioreduction of acetophenone is studied.