Email this article Efficient Synthesis and Biological Activity of Novel Indole Derivatives as VEGFR-2 Tyrosine Kinase Inhibitors
- Authors: Zhang C.1, Xu D.1, Wang J.1, Kang C.1
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Affiliations:
- College of Chemical Engineering
- Issue: Vol 87, No 12 (2017)
- Pages: 3006-3016
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221826
- DOI: https://doi.org/10.1134/S1070363217120465
- ID: 221826
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Abstract
A series of novel indole derivatives were synthesized as potent inhibitors for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase. Among those, compound 10b demonstrated the highest growth inhibition rate of 66.7% against the VEGFR-2 tyrosine kinase at 10 μM which indicates that indole-benzothiazole might be the favorable structure. The binding mode of compound 10b with VEGFR-2 tyrosine kinase was evaluated by molecular docking.
About the authors
C. Zhang
College of Chemical Engineering
Email: lvyingtao@qust.edu.cn
China, Qingdao, 266042
D. Xu
College of Chemical Engineering
Email: lvyingtao@qust.edu.cn
China, Qingdao, 266042
J. Wang
College of Chemical Engineering
Email: lvyingtao@qust.edu.cn
China, Qingdao, 266042
C. Kang
College of Chemical Engineering
Author for correspondence.
Email: lvyingtao@qust.edu.cn
China, Qingdao, 266042
