Synthesis, Characterization, and Anticancer Activity of Organotin(IV) Complexes with Sodium 3-(1H-Indol-3-yl)propanoate
- Authors: Shaheen F.1, Ali S.1, Shahzadi S.1
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Affiliations:
- Department of Chemistry
- Issue: Vol 87, No 12 (2017)
- Pages: 2937-2943
- Section: Letters to the Editor
- URL: https://journals.rcsi.science/1070-3632/article/view/221773
- DOI: https://doi.org/10.1134/S1070363217120350
- ID: 221773
Cite item
Abstract
Six organotin(IV) complexes have been synthesized by refluxing sodium salt of 3-(1H-indol-3-yl)-propanoic acid with di- and triorganotin chlorides in 1: 1 and 2: 1 molar ratios, respectively. These complexes have been characterized by elemental analysis, IR, and 1H, 13C, and 119Sn NMR spectral data. DNA binding studies were performed by viscometric measurements and UV-Vis spectroscopy. Both techniques indicated an intercalation mode of interaction. Cytotoxic activity of the ligand salt and organotin(IV) complexes 1–6 was tested against human ovarian cell line A2780. Results of bioassay revealed that organotin derivatives were more active than anticancer drug cis-platin. Triorganotin(IV) compounds had higher cytotoxic activity than corresponding diorganotin(IV) complexes.
About the authors
F. Shaheen
Department of Chemistry
Email: sairashahzadi@hotmail.com
Pakistan, Islamabad, 45320
S. Ali
Department of Chemistry
Author for correspondence.
Email: drsa54@hotmail.com
Pakistan, Islamabad, 45320
S. Shahzadi
Department of Chemistry; Department of Chemistry
Author for correspondence.
Email: sairashahzadi@hotmail.com
Pakistan, Islamabad, 45320; Faisalabad