Design and synthesis of new 1,2,3-triazole-pyrazole hybrids as antimicrobial agents
- Authors: Pervaram S.1, Ashok D.2, Rao B.A.2, Sarasija M.1, Reddy C.V.1
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Affiliations:
- Department of Chemistry
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Issue: Vol 87, No 10 (2017)
- Pages: 2454-2461
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221495
- DOI: https://doi.org/10.1134/S1070363217100280
- ID: 221495
Cite item
Abstract
In the present study, a series of novel 1,2,3-triazoles derivatives (4a–4c) were synthesized by the 1,3-dipolar cycloaddition (click-reaction) of 1-phenyl-3-[2-(prop-2-yn-1-yloxy)phenyl substituted]-1H-pyrazole-4-carbaldehyade (3a–3c) with various aryl azides in the presence of sodium ascorbate and copper sulphate with high yields. The required precursors 3a–3c were synthesized by the reaction of 1-(2-hydroxy phenyl substituted)ethanones (1a–1c) with propargyl bromide via 1-[2-(prop-2-yn-1-yloxy)phenyl substituted] ethanone (2a–2c), followed by reaction with phenyl hydrazine. The newly synthesized 1,2,3-triazole-pyrazole derivatives were characterized by analytical and spectral data. All synthesized compounds were evaluated in vitro for their antibacterial and antifungal activity. The most active compounds 4a5–4a7 demonstrated a broad spectrum of antibacterial activity against all strains used for testing. Compounds (4a4, 4b1, 4c1, 4c2) demonstrated significant antifungal activity at the concentration of 10 μg/mL.
About the authors
S. Pervaram
Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500085
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Author for correspondence.
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007
B. A. Rao
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500007
M. Sarasija
Department of Chemistry
Email: ashokdou@gmail.com
India, Karimnagar, Telangana, 505001
C. V. R. Reddy
Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, Telangana, 500085