N -substituted dibutoxyphosphorylacetimidates in phosphorylation reactions

V. E. Shishkin; Yu. V. Popov; O. V. Anishchenko; M. A. Shevchenko; S. M. Ledenev; A. A. Moroz; I. A. Kosheleva

doi:10.1134/S1070363217090390

N-substituted dibutoxyphosphorylacetimidates in phosphorylation reactions

Authors: Shishkin V.E.¹, Popov Y.V.¹, Anishchenko O.V.¹, Shevchenko M.A.¹, Ledenev S.M.¹, Moroz A.A.¹, Kosheleva I.A.¹
Affiliations:
1. Volgograd State Technical University
Issue: Vol 87, No 9 (2017)
Pages: 2133-2136
Section: Letters to the Editor
URL: https://journals.rcsi.science/1070-3632/article/view/221325
DOI: https://doi.org/10.1134/S1070363217090390
ID: 221325

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Abstract

Reaction of N-substituted dibutoxyphosphorylacetimidates with sodium followed by phosphorylation of sodium derivatives with dialkyl chlorophosphates and phenyl dichlorophosphate proceeds selectively under mild conditions to form products of phosphorylation of the methylene group. The synthesized compounds possess potential antisecretory, immunosuppressive, hypolipidemic, and other types of biological activity.