One-pot three-component green synthesis of novel dihydrophthalazine-1,4-diones


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Green and efficient one-pot three-component synthesis of novel 2-(7-amino-2,2-dimethyl-4-oxo-5-phenyl-4,5-dihydropyrano[2,3-d][1,3]dioxin-6-ylcarbonyl)-2,3-dihydrophthalazine-1,4-diones have been developed by condensing 3-(1,4-dioxo-1,2,3,4-tetrahydrophthalazin-2-yl)-3-oxopropanenitrile with benzaldehydes and Meldrum’s acid using L-proline as catalyst in ethanol at room temperature. The products have been isolated as pure compounds in good yields without using column chromatography.

作者简介

M. Suman

Process Research & Development

编辑信件的主要联系方式.
Email: sumandrreddysandra@gmail.com
印度, Srikakulam District, Pydibhimavaram, Ranasthalam Mandal, 532409

B. Vijayabhaskar

GVK Bio sciences PVT LTD

Email: sumandrreddysandra@gmail.com
印度, Survay no. 125 (part), 126, IDA, Mallapur, Hyderabad, 500076

U. Syam Kumar

Integrated Product Development, Innovation Plaza

Email: sumandrreddysandra@gmail.com
印度, R. R. Dist., Bachupalli, Qutubullapur, Andhra Pradesh, 500072

B. Venkateswara Rao

Department of Organic Chemistry, Foods, Drugs, and Water

Email: sumandrreddysandra@gmail.com
印度, Visakhapatnam, 530003

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