One-pot three-component green synthesis of novel dihydrophthalazine-1,4-diones
- Authors: Suman M.1, Vijayabhaskar B.2, Syam Kumar U.K.3, Venkateswara Rao B.4
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Affiliations:
- Process Research & Development
- GVK Bio sciences PVT LTD
- Integrated Product Development, Innovation Plaza
- Department of Organic Chemistry, Foods, Drugs, and Water
- Issue: Vol 87, No 9 (2017)
- Pages: 2039-2044
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221257
- DOI: https://doi.org/10.1134/S1070363217090201
- ID: 221257
Cite item
Abstract
Green and efficient one-pot three-component synthesis of novel 2-(7-amino-2,2-dimethyl-4-oxo-5-phenyl-4,5-dihydropyrano[2,3-d][1,3]dioxin-6-ylcarbonyl)-2,3-dihydrophthalazine-1,4-diones have been developed by condensing 3-(1,4-dioxo-1,2,3,4-tetrahydrophthalazin-2-yl)-3-oxopropanenitrile with benzaldehydes and Meldrum’s acid using L-proline as catalyst in ethanol at room temperature. The products have been isolated as pure compounds in good yields without using column chromatography.
Keywords
About the authors
M. Suman
Process Research & Development
Author for correspondence.
Email: sumandrreddysandra@gmail.com
India, Srikakulam District, Pydibhimavaram, Ranasthalam Mandal, 532409
B. Vijayabhaskar
GVK Bio sciences PVT LTD
Email: sumandrreddysandra@gmail.com
India, Survay no. 125 (part), 126, IDA, Mallapur, Hyderabad, 500076
U. K. Syam Kumar
Integrated Product Development, Innovation Plaza
Email: sumandrreddysandra@gmail.com
India, R. R. Dist., Bachupalli, Qutubullapur, Andhra Pradesh, 500072
B. Venkateswara Rao
Department of Organic Chemistry, Foods, Drugs, and Water
Email: sumandrreddysandra@gmail.com
India, Visakhapatnam, 530003
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