Synthesis of thiazole derivatives using magnetic nano zirconia–sulfuric acid as an efficient and recyclable catalyst in water

Abstract

Fe₃O₄ magnetic core covered by zirconia shell bearing sulfonic acid groups (Fe₃O₄@ZrO₂–SO₃H) was prepared and used as an efficient acidic catalyst in the synthesis of thiazole derivatives by the reaction of acyl chloride with ammonium thiocyanate, amino acids and alkyl bromides. Fe₃O₄@ZrO₂–SO₃H exhibited high catalytic activity in the synthesis of thiazole derivatives. This new catalytic method for thiazole derivatives provided rapid access to the desired compounds in high yields in water media upon refluxing followed by a simple work-up procedure. The developed method is a significant improvement of the currently available synthetic approaches to thiazole derivatives.