Synthesis of some new pyrazolyl-thiazolidinone derivatives starting from 1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazole-4-carboxaldehyde

Abstract

A novel synthetic approach to (E)-1-{[1-(3-chlorophenyl)-3-[(4-methoxyphenyl-1H-pyrazol-4-yl)- methylene]hydrazono}-3-phenylthiazolidin-4-one starting from the key intermediate thiosemicarbazone derivative is presented. The latter compound reacted with some aromatic and heterocyclic aldehydes to give (1-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}hydrazono)-5-(substituted benzylidene)-3-phenylthiazolidin-4-one derivatives.