An efficient reduction of nitro and bromine naphthalene derivatives
- Authors: Dong J.1, Zhang Q.1, Huang G.1, Meng Q.1, Li S.1
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Affiliations:
- School of Pharmacy
- Issue: Vol 87, No 4 (2017)
- Pages: 837-841
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/219428
- DOI: https://doi.org/10.1134/S1070363217040272
- ID: 219428
Cite item
Abstract
Reduction of 1,5-dimethoxy-4-nitronaphthalene by hydrazine hydrate was optimized in the course of current study. Influence of metals, temperature and solvents upon the process was tested. Yield of the reaction was the highest in the presence of Zn powder in DMF. Moderate heating made the process slightly more efficient than that at room temperature, whereas high temperature led to a decreased yield. The current approach made it possible to exclude high pressure and diminish experimental costs.
About the authors
J. Dong
School of Pharmacy
Email: qqmeng@sjtu.edu.cn
China, 800 Dongchuan Road, Shanghai, 200240
Q. Zhang
School of Pharmacy
Email: qqmeng@sjtu.edu.cn
China, 800 Dongchuan Road, Shanghai, 200240
G. Huang
School of Pharmacy
Email: qqmeng@sjtu.edu.cn
China, 800 Dongchuan Road, Shanghai, 200240
Q. Meng
School of Pharmacy
Author for correspondence.
Email: qqmeng@sjtu.edu.cn
China, 800 Dongchuan Road, Shanghai, 200240
S. Li
School of Pharmacy
Email: qqmeng@sjtu.edu.cn
China, 800 Dongchuan Road, Shanghai, 200240