Synthesis and biological evaluation of 1,3,4-oxadiazole fused pyridine derivatives as antibacterial and antifungal agents

Abstract

A series of novel 1,3,4-oxadiazole fused pyridine derivatives were synthesized 11a–11f and their structures confirmed by IR, ¹H NMR and Mass spectral data. The compounds were evaluated for their antibacterial and antifungal activities against Gram negative and positive bacterial strains including Escherichia coli (MTCC 443), K. Pneumoniae (MTCC 109), S. Aureus (MTCC 96), B. Subtilis (MTCC 441) and Sclerotium rolfsii, Macrophomina phaseolina. Compounds 11d, 11e, and 11f demonstrated high antibacterial activity.