Synthesis and antimicrobial activity of novel 5-[(1 H -indol-3-yl)methylene]thiazolidine-2,4-dione–[1,2,3]triazole hybrids

L. Kamala; B. S. Veena; P. V. Anantha Lakshmi; P. Vasantha; E. Sujatha

doi:10.1134/S107036321702027X

Synthesis and antimicrobial activity of novel 5-[(1H-indol-3-yl)methylene]thiazolidine-2,4-dione–[1,2,3]triazole hybrids

Authors: Kamala L.¹, Veena B.S.², Anantha Lakshmi P.V.¹, Vasantha P.¹, Sujatha E.²
Affiliations:
1. Department of Chemistry, University College for Women
2. Department of Botany, University College of Science
Issue: Vol 87, No 2 (2017)
Pages: 316-321
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/218480
DOI: https://doi.org/10.1134/S107036321702027X
ID: 218480

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Abstract

5-[(1H-Indol-3-yl)methylene]thiazolidine-2,4-dione–[1,2,3]triazole hybrid derivatives were synthesized by click chemistry reaction and screened for antimicrobial activity against Gram positive and Gram negative bacteria and fungal species. All synthesized compounds were characterized by ¹H and ¹³C NMR, IR and MS spectra. Antibacterial study indicated that several products demonstrated high activity and some products were determined to be potentially antifungal active agents.