Bis(4-nitrophenyl)phosphorylazide as a reagent for direct azidation of polyfunctional derivatives of pyrimidin-4(3 Н )-one

I. A. Novakov; A. S. Babushkin; L. L. Brunilina; M. B. Navrotskii; B. S. Orlinson; M. D. Robinovich; A. S. Yablokov

doi:10.1134/S1070363217020116

Bis(4-nitrophenyl)phosphorylazide as a reagent for direct azidation of polyfunctional derivatives of pyrimidin-4(3Н)-one

Authors: Novakov I.A.¹, Babushkin A.S.¹, Brunilina L.L.¹, Navrotskii M.B.¹, Orlinson B.S.¹, Robinovich M.D.¹, Yablokov A.S.¹
Affiliations:
1. Volgograd State Technical University
Issue: Vol 87, No 2 (2017)
Pages: 219-223
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/218177
DOI: https://doi.org/10.1134/S1070363217020116
ID: 218177

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Abstract

The application of bis-(4-nitrophenyl)phosphorylazide–1,8-diazabicyclo[5.4.0]undec-7-ene system for direct transformation of polyfunctional derivatives of pyrimidin-4(3H)-one in the corresponding 4-azidopyrimidines has been suggested for the first time. Using this system, novel 4-azido-6-(2,6-dihalo-α-methoxybenzyl)-5-methyl-2-(nitroamino)pyrimidines have been obtained in good yield under mild conditions.