Email this article Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives
- Authors: El-Azab A.S.1,2, Ghabbour H.A.1,3, El-Husseiny W.M.4, Maarouf A.R.3,1, Mohamed M.A.2,1, Abdel-Aziz A.A.1,3
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Affiliations:
- Department of Pharmaceutical Chemistry, College of Pharmacy
- Department of Organic Chemistry, Faculty of Pharmacy
- Department of Medicinal Chemistry, Faculty of Pharmacy
- Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy
- Issue: Vol 86, No 12 (2016)
- Pages: 2837-2844
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/217008
- DOI: https://doi.org/10.1134/S1070363216120471
- ID: 217008
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Abstract
Hydrazones 2–22 were synthesized via the reaction of acetophenone with isatin derivatives and anhydrous hydrazine promoted by BF3 as a Lewis acid at 0°C. Structures of the synthesized hydrazones were determined on the basis of NMR and X-ray crystallographic analyses.
About the authors
A. S. El-Azab
Department of Pharmaceutical Chemistry, College of Pharmacy; Department of Organic Chemistry, Faculty of Pharmacy
Author for correspondence.
Email: adelazaba@yahoo.com
Saudi Arabia, Riyadh, 11451; Cairo
H. A. Ghabbour
Department of Pharmaceutical Chemistry, College of Pharmacy; Department of Medicinal Chemistry, Faculty of Pharmacy
Email: adelazaba@yahoo.com
Saudi Arabia, Riyadh, 11451; Mansoura, 35516
W. M. El-Husseiny
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy
Email: adelazaba@yahoo.com
Egypt, Mansoura, 35516
A. R. Maarouf
Department of Medicinal Chemistry, Faculty of Pharmacy; Department of Pharmaceutical Chemistry, College of Pharmacy
Email: adelazaba@yahoo.com
Egypt, Mansoura, 35516; Gamasa City
M. A. Mohamed
Department of Organic Chemistry, Faculty of Pharmacy; Department of Pharmaceutical Chemistry, College of Pharmacy
Email: adelazaba@yahoo.com
Egypt, Cairo; AlKharj
A. A.-M. Abdel-Aziz
Department of Pharmaceutical Chemistry, College of Pharmacy; Department of Medicinal Chemistry, Faculty of Pharmacy
Email: adelazaba@yahoo.com
Saudi Arabia, Riyadh, 11451; Mansoura, 35516
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