Synthesis of chemical compounds of chitosan with betulin under nearly homogeneous conditions


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Abstract

Chemical compounds of chitosan with betulin have been synthesized with the use of chitosan gels in alcoholic and acetic acid dispersions under nearly homogeneous conditions. The resulting biphilic compounds contain up to one betulin residue per 2–3 chitosan units. The formation of chemical compounds of chitosan with betulin has been confirmed by several physicochemical methods. The procedure developed for the preparation of chitosan gels with alcohol-containing dispersion medium makes it possible to carry out chitosan reactions with compounds poorly soluble in aqueous and acetic acid media.

About the authors

E. N. Fedoseeva

Research Institute of Chemistry

Author for correspondence.
Email: el.nik.fedoseeva@gmail.com
Russian Federation, pr. Gagarina 23, Nizhny Novgorod, 603950

V. F. Ur’yash

Research Institute of Chemistry

Email: el.nik.fedoseeva@gmail.com
Russian Federation, pr. Gagarina 23, Nizhny Novgorod, 603950

N. Yu. Kokurina

Research Institute of Chemistry

Email: el.nik.fedoseeva@gmail.com
Russian Federation, pr. Gagarina 23, Nizhny Novgorod, 603950

V. B. Fedoseev

Research Institute of Chemistry; Razuvaev Institute of Organometallic Chemistry

Email: el.nik.fedoseeva@gmail.com
Russian Federation, pr. Gagarina 23, Nizhny Novgorod, 603950; ul. Tropinina 49, Nizhny Novgorod, 603137


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