Synthesis and characterization of cobalt and manganese complexes of indomethacin and comparative study of local analgesic, anti-inflammatory, and anti-ulcerogenic properties
- Authors: Sukul A.1,2, Poddar S.K.2, Saha S.K.2, Das S.C.2
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Affiliations:
- Department of Pharmacy
- Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy
- Issue: Vol 86, No 8 (2016)
- Pages: 1935-1943
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/216024
- DOI: https://doi.org/10.1134/S1070363216080260
- ID: 216024
Cite item
Abstract
The aim of the study was to synthesize cobalt and manganese complexes of indomethacin and their biological activity screening to uncover. The structures of metal complexes were elucidated by FT-IR, UV-Vis and atomic absorption spectroscopy, X-ray diffraction and calorimetric DSC. Heat radiant tail-flick test for local analgesic activity of cobalt complex of indomethacin in the doses of 50 and 100 μg/mL demonstrated potent local analgesic response. Manganese complex of indomethacin exhibited similar potent of activity at the dose of 100 μg/mL. Anti-inflammatory study of the indomethacin-manganese and indomethacin-cobalt complexes demonstrated their activity (paw edema inhibition of 71.67% at 20 mg/kg dose in the 1 h and 83.33% at 10 mg/kg dose in the 4 h) comparable with the standard diclofenac sodium. Gastrointestinal efficacy of cobalt and manganese complexes was close to that of indomethacin.
About the authors
A. Sukul
Department of Pharmacy; Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy
Author for correspondence.
Email: abhijitsukul007@gmail.com
Bangladesh, Dhaka, 1205; Dhaka, 1000
S. K. Poddar
Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy
Email: abhijitsukul007@gmail.com
Bangladesh, Dhaka, 1000
S. K. Saha
Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy
Email: abhijitsukul007@gmail.com
Bangladesh, Dhaka, 1000
S. C. Das
Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy
Email: abhijitsukul007@gmail.com
Bangladesh, Dhaka, 1000