Synthesis, single crystal x-ray analysis, and antimicrobial activity of new (22E)-N'-(4-methoxybenzylidene)-2-[3-cyano-7,8-dihydro-4-(5-methylfuran-2-yl)-2-oxo-2H-pyrano[4,3-b]pyridin-1(5H)-yl]acetohydrazide

Abstract

(22E)-N'-(4-Methoxybenzylidene)-2-[3-cyano-7,8-dihydro-4-(5-methylfuran-2-yl)-2-oxo-2H-pyrano[ 4,3-b]pyridin-1(5H)-yl]acetohydrazide (2) was synthesized from 2-[3-cyano-7,8-dihydro-4-(5-methylfuran- 2-yl)-2-oxo-2H-pyrano[4,3-b]pyridin-1(5H)-yl]acetohydrazide (1) as starting material with 4-methoxybenzaldehyde. The product 22 was evaluated for antimicrobial activity against gram positive and gram negative bacteria in comparison with Vebromycine as the standard antibiotics. Compound 2, C₂₄H₂₂N₄O₅, crystallized as triclinic, P-1, a = 8.3496(5) Å, b = 10.9465(9) Å, c = 12.1495(9) Å, a = 74.694(4)°, β = 84.793(3)°, γ = 84.495 (3)°, V = 1063.64(13) ų, Z = 2.