Email this article Synthesis of novel 2-phenoxybenzo[g][1,2,4]triazolo[1,5-a]quinazoline and its derivatives starting with diphenyl-N-cyanoimidocarbonate
- Authors: Al-Salahi R.A.1, Marzouk M.S.1,2
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Affiliations:
- Department of Pharmaceutical Chemistry, College of Pharmacy
- Chemistry of Natural Products Group, Center of Excellence for Advanced Sciences
- Issue: Vol 86, No 7 (2016)
- Pages: 1741-1746
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/215820
- DOI: https://doi.org/10.1134/S1070363216070331
- ID: 215820
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Abstract
Cyclocondensation reaction of 3-hydrazinyl-2-naphthoic acid with diphenyl-N-cyanoimidocarbonate furnished the target 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazolin-5(4H)-one (1) in high yield. Alkylation, thionation and chlorination of the lactam group in the compound 1 produced a variety of derivatives 2–17. Their structures were characterized by NMR and HREI-MS analyses.
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About the authors
R. A. Al-Salahi
Department of Pharmaceutical Chemistry, College of Pharmacy
Author for correspondence.
Email: rashad76@outlook.com
Saudi Arabia, Riyadh, 11451
M. S. Marzouk
Department of Pharmaceutical Chemistry, College of Pharmacy; Chemistry of Natural Products Group, Center of Excellence for Advanced Sciences
Author for correspondence.
Email: msmarzouk@yahoo.co.uk
Saudi Arabia, Riyadh, 11451; Dokki, Cairo, 12622
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