Synthesis and properties of 4-phosphorylated derivatives of 5-hydroxyalkylamino-1,3-oxazoles


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Abstract

Reactions of derivatives of diethyl 1-acylamino-2,2,2-trichloroethylphosphonates with different pharmacophore aminoalkanols afforded new 5-hydroxyalkylamino-1,3-oxazole derivatives. The latter are promising substrates for producing new 4-phosphorylated peptidomimetics containing alcohol residues.

About the authors

E. R. Abdurakhmanova

Institute of Bioorganic Chemistry and Petrochemistry

Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660

E. I. Lukashuk

Institute of Bioorganic Chemistry and Petrochemistry

Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660

A. V. Golovchenko

Institute of Bioorganic Chemistry and Petrochemistry

Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660

V. S. Brovarets

Institute of Bioorganic Chemistry and Petrochemistry

Author for correspondence.
Email: brovarets@bpci.kiev.ua
Ukraine, ul. Murmanskaya 1, Kyiv, 02660


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