Green synthesis of new Ge(IV) complexes with bio-potent ligands and their antimicrobial, DNA cleavage, and antioxidant activities
- Authors: Fahmi N.1, Khedar R.1, Singh R.V.1
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Affiliations:
- Department of Chemistry
- Issue: Vol 86, No 4 (2016)
- Pages: 958-964
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214830
- DOI: https://doi.org/10.1134/S1070363216040344
- ID: 214830
Cite item
Abstract
Green microwave supported synthesis, spectral, antimicrobial, DNA cleavage, and antioxidant studies of Ge(IV) complexes with bio-potent ligands, 1-acetylferrocenehydrazinecarboxamide (L1H) and 1-acetylferrocenehydrazinecarbothioamide (L2H) have been carried out. The ligands and their respective complexes have been characterized on the basis of elemental analysis, IR, 1H and 13C NMR spectra, and X-ray powder diffraction studies. The ligands are coordinated to the Ge(IV) via azomethine nitrogen and thiolic sulfur atom/ enolic oxygen atom. Both ligands and their complexes demonstrated appreciable fungicidal and bactericidal properties. The metal complexes demonstrated stronger antimicrobial than the respective free ligands. DNA cleavage activity of the complexes study revealed higher activity of the complexes than the ligands. Antioxidant activity of the complexes was tested for their hydrogen peroxide scavenging.
About the authors
N. Fahmi
Department of Chemistry
Author for correspondence.
Email: nighat.fahmi@gmail.com
India, Jaipur, 302004
R. Khedar
Department of Chemistry
Email: nighat.fahmi@gmail.com
India, Jaipur, 302004
R. V. Singh
Department of Chemistry
Email: nighat.fahmi@gmail.com
India, Jaipur, 302004
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