Email this article Synthesis of novel heptaplatin derivatives and evaluation of their ability to inhibit proliferation of cancer cell lines
- Authors: Xu W.1, Wang D.C.2
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Affiliations:
- Department of Chemical Engineering
- College of Pharmaceutical Sciences
- Issue: Vol 86, No 4 (2016)
- Pages: 939-943
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214783
- DOI: https://doi.org/10.1134/S1070363216040319
- ID: 214783
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Abstract
A series of novel heptaplatin derivatives were synthesized and evaluated for their ability to inhibit growth of two cancer cell lines: human colon carcinoma cell line HCT-8 and human hepatocarcinoma cell line Bel-7402. Majority of the synthesized compounds demonstrated superior activity against cancer cell lines compared to heptaplatin. Specifically, compounds 5a and 5b (5 µg/mL) had more pronounced efficacy against the HCT-8 cell line while 6b and 6c (0.5 µg/mL) had higher efficacy against Bel-7402 cell line.
About the authors
W. Xu
Department of Chemical Engineering
Author for correspondence.
Email: tracy_xu1984@yeah.net
China, Taizhou, 225300
D. C. Wang
College of Pharmaceutical Sciences
Email: tracy_xu1984@yeah.net
China, Nanjing, 210009
