Microwave-assisted synthesis of 1-{2-[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones and their antimicrobial activity
- Authors: Ashok D.1, Padmavati K.1
-
Affiliations:
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Issue: Vol 86, No 4 (2016)
- Pages: 907-914
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214717
- DOI: https://doi.org/10.1134/S1070363216040253
- ID: 214717
Cite item
Abstract
A series of new (E)-1-{2-[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones (3a–3i) has been synthesized via copper-catalyzed 1,3-dipolar azide-alkyne cycloaddition reaction (CuAAC) of benzyl azide with substituted (E)-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-1-[2-(prop-2-ynyloxy)phenyl]prop-2-en-1-ones (2a–2i). The synthesized compounds have been characterized by their IR, lH, 13C NMR spectra, and mass spectroscopy data. All the compounds have been screened for antimicrobial activity.
About the authors
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Author for correspondence.
Email: ashokdou@gmail.com
India, Hyderabad, 500007
K. Padmavati
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: ashokdou@gmail.com
India, Hyderabad, 500007
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