DNA binding, DNA cleavage, and cellular imaging of a copper(II) complex based on curcumin
- Авторлар: Si G.1, Jiang B.1, Wei D.1, Wang J.1, Zhou S.1
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Мекемелер:
- Center of Modern Experimental Technology
- Шығарылым: Том 86, № 3 (2016)
- Беттер: 718-722
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214473
- DOI: https://doi.org/10.1134/S1070363216030336
- ID: 214473
Дәйексөз келтіру
Аннотация
Binding property between CT-DNA and a Cu(II) complex, namely CuL2, where HL = 1,7-bis(4-butoxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, was determined by UV–Vis absorption, fluorescence spectroscopy, and viscosity measurements. The results showed that the binding of the complex with CT-DNA was through the intercalative mode and the binding constant (Kb) value was found to be 3.82 × 104 M. DNA cleavage studies showed that CuL2 exhibited effective cleavage activity on pBR322 plasmid DNA in absence of external agents. Additionally, cellular imaging studies also indicated that CuL2 has a higher toxicity to MCF-7 cell lines compared with its corresponding ligand HL.
Негізгі сөздер
Авторлар туралы
G. Si
Center of Modern Experimental Technology
Email: zshuangsheng@126.com
ҚХР, Hefei, 230039
B. Jiang
Center of Modern Experimental Technology
Email: zshuangsheng@126.com
ҚХР, Hefei, 230039
D. Wei
Center of Modern Experimental Technology
Email: zshuangsheng@126.com
ҚХР, Hefei, 230039
J. Wang
Center of Modern Experimental Technology
Хат алмасуға жауапты Автор.
Email: jiafeng_wang2002@163.com
ҚХР, Hefei, 230039
S. Zhou
Center of Modern Experimental Technology; Center of Modern Experimental Technology
Хат алмасуға жауапты Автор.
Email: zshuangsheng@126.com
ҚХР, Hefei, 230039; Hefei, 230039
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