Synthesis and anticancer activity evaluation of ( E )-3-{[5-(aryl)-1,3,4-oxadiazol-2-yl]methyl}-5-(3,4,5-trimethoxybenzylidene)thiazolidine-2,4-diones

D. Ashok; B. Vanaja

doi:10.1134/S1070363216030270

Synthesis and anticancer activity evaluation of (E)-3-{[5-(aryl)-1,3,4-oxadiazol-2-yl]methyl}-5-(3,4,5-trimethoxybenzylidene)thiazolidine-2,4-diones

Authors: Ashok D.¹, Vanaja B.¹
Affiliations:
1. Green and Medicinal Chemistry Laboratory, Department of Chemistry
Issue: Vol 86, No 3 (2016)
Pages: 681-685
Section: Article
URL: https://journals.rcsi.science/1070-3632/article/view/214366
DOI: https://doi.org/10.1134/S1070363216030270
ID: 214366

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Abstract
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Abstract

A series of new substituted (E)-3-{[5-(aryl)-1,3,4-oxadiazol-2-yl]methyl}-5-(3,4,5-trimethoxy-benzylidene) thiazolidine-2,4-diones have been synthesized. The products have been characterized by their IR, ¹H NMR, ¹³C NMR, and mass spectral properties and evaluated for anticancer activity against four human cancer cell lines: A549, A375, MCF-7, and HT-29.

Keywords

1,3,4-oxadiazole, thiazolidine-2,4-dione, cytotoxicity

About the authors

D. Ashok

Green and Medicinal Chemistry Laboratory, Department of Chemistry

Author for correspondence.
Email: ashokdou@gmail.com
India, Hyderabad, 500007

B. Vanaja