Email this article NMR study of 1,7-diamino-4-oxyheptane-1,1,7,7-tetraphosphonic acid interaction with samarium(III) cation
- Authors: Kalashnikova I.P.1,2, Ragulin V.V.2, Zavel’skii V.O.2, Kodina G.E.3, Tsivadze A.Y.1, Tsebrikova G.S.1, Baulin V.E.1,2
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Affiliations:
- Frumkin Institute of Physical Chemistry and Electrochemistry
- Institute of Physiologically Active Compounds
- Burnazyan Federal Medical Biophysical Center
- Issue: Vol 86, No 3 (2016)
- Pages: 639-644
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/214286
- DOI: https://doi.org/10.1134/S107036321603021X
- ID: 214286
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Abstract
1,7-Diamino-4-oxypentane-1,1,7,7-tetraphosphonic acid has been synthesized while searching for potential components for 153Sm radiopharmaceuticals. Its interaction with samarium(III) cation has been studied by 13C and 31P NMR spectroscopy in comparison with 1,5-diamino-3-oxypentane-N,N'-tetra-(methylenephosphonic acid) which is the ligand component of the osteotropic drug Samarium 153Sm oxabifore. NMR spectroscopy provides a simple, convenient, and informative method for studying interactions between the ligand and prospective radionuclide cation.
About the authors
I. P. Kalashnikova
Frumkin Institute of Physical Chemistry and Electrochemistry; Institute of Physiologically Active Compounds
Email: tsebrikova@yandex.ru
Russian Federation, Leninskii pr. 31/4, Moscow, 119071; Severnyi proezd 1, Chernogolovka, Moscow oblast
V. V. Ragulin
Institute of Physiologically Active Compounds
Email: tsebrikova@yandex.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, Moscow oblast
V. O. Zavel’skii
Institute of Physiologically Active Compounds
Email: tsebrikova@yandex.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, Moscow oblast
G. E. Kodina
Burnazyan Federal Medical Biophysical Center
Email: tsebrikova@yandex.ru
Russian Federation, ul. Zhivopisnaya 46, Moscow, 123098
A. Yu. Tsivadze
Frumkin Institute of Physical Chemistry and Electrochemistry
Email: tsebrikova@yandex.ru
Russian Federation, Leninskii pr. 31/4, Moscow, 119071
G. S. Tsebrikova
Frumkin Institute of Physical Chemistry and Electrochemistry
Author for correspondence.
Email: tsebrikova@yandex.ru
Russian Federation, Leninskii pr. 31/4, Moscow, 119071
V. E. Baulin
Frumkin Institute of Physical Chemistry and Electrochemistry; Institute of Physiologically Active Compounds
Email: tsebrikova@yandex.ru
Russian Federation, Leninskii pr. 31/4, Moscow, 119071; Severnyi proezd 1, Chernogolovka, Moscow oblast
