Email this article A novel dinuclear Pd(II) complex dibridged by 2,2-iminodibenzoic acid: Synthesis, characterization, and biological activity
- Authors: Gao E.J.1, Ma X.Y.1, Wang B.1, Meng Y.1, Zhao F.C.1, Jin H.T.1, Liu S.J.1, Ge J.1, Sun Y.G.1, Zhang W.Z.1, Zhu M.C.1
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Affiliations:
- Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
- Issue: Vol 42, No 11 (2016)
- Pages: 749-754
- Section: Article
- URL: https://journals.rcsi.science/1070-3284/article/view/213348
- DOI: https://doi.org/10.1134/S1070328416110038
- ID: 213348
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Abstract
The novel dinuclear complex [Pd2(L)2(Phen)2] (Phen = 1,10-phenanthroline, H2L = 2,2'-iminodibenzoic acid) was synthesized and characterized by IR spectra, element analysis, and X-ray single-crystal diffraction (СIF file CCDC no. 1469344). The competitive binding study with ethidium bromide (EtBr) was tested by fluorescence measurement. The result indicated that the complex has an ability to displace the EtBr bound to DNA. Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA. Apoptotic research indicated that [Pd2(L)2(Phen)2] exhibited significant cancer cell inhibitory rate.
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About the authors
E. J. Gao
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Author for correspondence.
Email: enjungao@163.com
China, Shenyang, 110142
X. Y. Ma
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang, 110142
B. Wang
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang, 110142
Y. Meng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang, 110142
F. C. Zhao
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang, 110142
H. T. Jin
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang, 110142
S. J. Liu
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang, 110142
J. Ge
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang, 110142
Y. G. Sun
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang, 110142
W. Z. Zhang
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
China, Shenyang, 110142
M. C. Zhu
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Author for correspondence.
Email: mczhu@syuct.edu.cn
China, Shenyang, 110142
