Enviar artigo por via de e-mail A novel dinuclear Pd(II) complex dibridged by 2,2-iminodibenzoic acid: Synthesis, characterization, and biological activity
- Autores: Gao E.J.1, Ma X.Y.1, Wang B.1, Meng Y.1, Zhao F.C.1, Jin H.T.1, Liu S.J.1, Ge J.1, Sun Y.G.1, Zhang W.Z.1, Zhu M.C.1
-
Afiliações:
- Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
- Edição: Volume 42, Nº 11 (2016)
- Páginas: 749-754
- Seção: Article
- URL: https://journals.rcsi.science/1070-3284/article/view/213348
- DOI: https://doi.org/10.1134/S1070328416110038
- ID: 213348
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
The novel dinuclear complex [Pd2(L)2(Phen)2] (Phen = 1,10-phenanthroline, H2L = 2,2'-iminodibenzoic acid) was synthesized and characterized by IR spectra, element analysis, and X-ray single-crystal diffraction (СIF file CCDC no. 1469344). The competitive binding study with ethidium bromide (EtBr) was tested by fluorescence measurement. The result indicated that the complex has an ability to displace the EtBr bound to DNA. Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA. Apoptotic research indicated that [Pd2(L)2(Phen)2] exhibited significant cancer cell inhibitory rate.
Palavras-chave
Sobre autores
E. Gao
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Autor responsável pela correspondência
Email: enjungao@163.com
República Popular da China, Shenyang, 110142
X. Ma
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang, 110142
B. Wang
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang, 110142
Y. Meng
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang, 110142
F. Zhao
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang, 110142
H. Jin
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang, 110142
S. Liu
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang, 110142
J. Ge
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang, 110142
Y. Sun
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang, 110142
W. Zhang
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang, 110142
M. Zhu
Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry
Autor responsável pela correspondência
Email: mczhu@syuct.edu.cn
República Popular da China, Shenyang, 110142
Arquivos suplementares
