Email this article Quantification of cerebral aspartate concentration in vivo using proton magnetic resonance spectroscopy
- Authors: Menshchikov P.E.1,2, Akhadov T.A.2, Semenova N.A.1,2,3
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Affiliations:
- Semenov Institute of Chemical Physics
- Research Institute of Emergency Children’s Surgery and Traumatology
- Emanuel Institute of Biochemical Physics
- Issue: Vol 44, No 3 (2017)
- Pages: 56-60
- Section: Article
- URL: https://journals.rcsi.science/1068-3356/article/view/228264
- DOI: https://doi.org/10.3103/S1068335617030022
- ID: 228264
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Abstract
The 1Н MRS is a unique method allowing in vivo observation of concentrations of proton-containing chemical compounds in human tissues and organs. The main problem of this technique is the signal overlap caused by the similarity of structural fragments of variousmetabolites. To separate overlapped signals, the J-modulation technique for editing spectra, based on the spin–spin interaction can be used. In this study, a method of direct observation of the lifetime aspartate concentration in local regions of the human brain, based on the MEGA-PRESS pulse sequence, is developed for the first time.
About the authors
P. E. Menshchikov
Semenov Institute of Chemical Physics; Research Institute of Emergency Children’s Surgery and Traumatology
Author for correspondence.
Email: peeterem@gmail.com
Russian Federation, ul. Kosygina 4, Moscow, 119991; ul. Bolshaya Polyanka 22, Moscow, 119180
T. A. Akhadov
Research Institute of Emergency Children’s Surgery and Traumatology
Email: peeterem@gmail.com
Russian Federation, ul. Bolshaya Polyanka 22, Moscow, 119180
N. A. Semenova
Semenov Institute of Chemical Physics; Research Institute of Emergency Children’s Surgery and Traumatology; Emanuel Institute of Biochemical Physics
Email: peeterem@gmail.com
Russian Federation, ul. Kosygina 4, Moscow, 119991; ul. Bolshaya Polyanka 22, Moscow, 119180; ul. Kosygina 26, Moscow, 119334
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