Quantification of cerebral aspartate concentration in vivo using proton magnetic resonance spectroscopy


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Somente assinantes

Resumo

The 1Н MRS is a unique method allowing in vivo observation of concentrations of proton-containing chemical compounds in human tissues and organs. The main problem of this technique is the signal overlap caused by the similarity of structural fragments of variousmetabolites. To separate overlapped signals, the J-modulation technique for editing spectra, based on the spin–spin interaction can be used. In this study, a method of direct observation of the lifetime aspartate concentration in local regions of the human brain, based on the MEGA-PRESS pulse sequence, is developed for the first time.

Sobre autores

P. Menshchikov

Semenov Institute of Chemical Physics; Research Institute of Emergency Children’s Surgery and Traumatology

Autor responsável pela correspondência
Email: peeterem@gmail.com
Rússia, ul. Kosygina 4, Moscow, 119991; ul. Bolshaya Polyanka 22, Moscow, 119180

T. Akhadov

Research Institute of Emergency Children’s Surgery and Traumatology

Email: peeterem@gmail.com
Rússia, ul. Bolshaya Polyanka 22, Moscow, 119180

N. Semenova

Semenov Institute of Chemical Physics; Research Institute of Emergency Children’s Surgery and Traumatology; Emanuel Institute of Biochemical Physics

Email: peeterem@gmail.com
Rússia, ul. Kosygina 4, Moscow, 119991; ul. Bolshaya Polyanka 22, Moscow, 119180; ul. Kosygina 26, Moscow, 119334

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Allerton Press, Inc., 2017