Quantification of cerebral aspartate concentration in vivo using proton magnetic resonance spectroscopy

Resumo

The ¹Н MRS is a unique method allowing in vivo observation of concentrations of proton-containing chemical compounds in human tissues and organs. The main problem of this technique is the signal overlap caused by the similarity of structural fragments of variousmetabolites. To separate overlapped signals, the J-modulation technique for editing spectra, based on the spin–spin interaction can be used. In this study, a method of direct observation of the lifetime aspartate concentration in local regions of the human brain, based on the MEGA-PRESS pulse sequence, is developed for the first time.