Отправить статью по E-mail Quantification of cerebral aspartate concentration in vivo using proton magnetic resonance spectroscopy
- Авторы: Menshchikov P.E.1,2, Akhadov T.A.2, Semenova N.A.1,2,3
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Учреждения:
- Semenov Institute of Chemical Physics
- Research Institute of Emergency Children’s Surgery and Traumatology
- Emanuel Institute of Biochemical Physics
- Выпуск: Том 44, № 3 (2017)
- Страницы: 56-60
- Раздел: Article
- URL: https://journals.rcsi.science/1068-3356/article/view/228264
- DOI: https://doi.org/10.3103/S1068335617030022
- ID: 228264
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Аннотация
The 1Н MRS is a unique method allowing in vivo observation of concentrations of proton-containing chemical compounds in human tissues and organs. The main problem of this technique is the signal overlap caused by the similarity of structural fragments of variousmetabolites. To separate overlapped signals, the J-modulation technique for editing spectra, based on the spin–spin interaction can be used. In this study, a method of direct observation of the lifetime aspartate concentration in local regions of the human brain, based on the MEGA-PRESS pulse sequence, is developed for the first time.
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Об авторах
P. Menshchikov
Semenov Institute of Chemical Physics; Research Institute of Emergency Children’s Surgery and Traumatology
Автор, ответственный за переписку.
Email: peeterem@gmail.com
Россия, ul. Kosygina 4, Moscow, 119991; ul. Bolshaya Polyanka 22, Moscow, 119180
T. Akhadov
Research Institute of Emergency Children’s Surgery and Traumatology
Email: peeterem@gmail.com
Россия, ul. Bolshaya Polyanka 22, Moscow, 119180
N. Semenova
Semenov Institute of Chemical Physics; Research Institute of Emergency Children’s Surgery and Traumatology; Emanuel Institute of Biochemical Physics
Email: peeterem@gmail.com
Россия, ul. Kosygina 4, Moscow, 119991; ul. Bolshaya Polyanka 22, Moscow, 119180; ul. Kosygina 26, Moscow, 119334
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