Effect of Gallium Carrier in 68Ga-Ethylenediaminetetrakis (Methylene Phosphonic Acid) on its Behavior in Laboratory Animals

Resumo

This paper concerns the study of the effect of the stable gallium carrier and its concentration on the biodistribution of a new osteotropic compound based on N,N,N′N′-ethylenediaminetetrakis (methylene phosphonic acid) and gallium-68 (⁶⁸Ga-EDTMP). The studies are performed on intact Wistar rats. It is shown that the bone tissue activity increases as the carrier is added, whereas it decreases in internals and tissues. The carrier concentration has no significant effect on the ⁶⁸Ga-EDTMP.