Email this article Effect of Gallium Carrier in 68Ga-Ethylenediaminetetrakis (Methylene Phosphonic Acid) on its Behavior in Laboratory Animals
- Authors: Petriev V.M.1,2, Tishchenko V.K.1,2, Stepchenkova E.D.1,2, Zavestovskaya I.N.2,3, Shegai P.V.1, Ivanov S.A.1, Karpin A.D.1
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Affiliations:
- Tsyb Medical Radiological Research Center
- National Research Nuclear University “MEPhI”
- Lebedev Physical Institute
- Issue: Vol 46, No 10 (2019)
- Pages: 319-323
- Section: Article
- URL: https://journals.rcsi.science/1068-3356/article/view/229088
- DOI: https://doi.org/10.3103/S1068335619100051
- ID: 229088
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Abstract
This paper concerns the study of the effect of the stable gallium carrier and its concentration on the biodistribution of a new osteotropic compound based on N,N,N′N′-ethylenediaminetetrakis (methylene phosphonic acid) and gallium-68 (68Ga-EDTMP). The studies are performed on intact Wistar rats. It is shown that the bone tissue activity increases as the carrier is added, whereas it decreases in internals and tissues. The carrier concentration has no significant effect on the 68Ga-EDTMP.
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About the authors
V. M. Petriev
Tsyb Medical Radiological Research Center; National Research Nuclear University “MEPhI”
Author for correspondence.
Email: petriev@mrrc.obninsk.ru
Russian Federation, 4 Koroleva St., Obninsk, Kaluga oblast, 249036; 31 Kashirskoe Sh., Moscow, 115409
V. K. Tishchenko
Tsyb Medical Radiological Research Center; National Research Nuclear University “MEPhI”
Email: petriev@mrrc.obninsk.ru
Russian Federation, 4 Koroleva St., Obninsk, Kaluga oblast, 249036; 31 Kashirskoe Sh., Moscow, 115409
E. D. Stepchenkova
Tsyb Medical Radiological Research Center; National Research Nuclear University “MEPhI”
Email: petriev@mrrc.obninsk.ru
Russian Federation, 4 Koroleva St., Obninsk, Kaluga oblast, 249036; 31 Kashirskoe Sh., Moscow, 115409
I. N. Zavestovskaya
National Research Nuclear University “MEPhI”; Lebedev Physical Institute
Email: petriev@mrrc.obninsk.ru
Russian Federation, 31 Kashirskoe Sh., Moscow, 115409; 53 Leninskii Pr., Moscow, 119991
P. V. Shegai
Tsyb Medical Radiological Research Center
Email: petriev@mrrc.obninsk.ru
Russian Federation, 4 Koroleva St., Obninsk, Kaluga oblast, 249036
S. A. Ivanov
Tsyb Medical Radiological Research Center
Email: petriev@mrrc.obninsk.ru
Russian Federation, 4 Koroleva St., Obninsk, Kaluga oblast, 249036
A. D. Karpin
Tsyb Medical Radiological Research Center
Email: petriev@mrrc.obninsk.ru
Russian Federation, 4 Koroleva St., Obninsk, Kaluga oblast, 249036
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