Effect of Gallium Carrier in 68Ga-Ethylenediaminetetrakis (Methylene Phosphonic Acid) on its Behavior in Laboratory Animals
- Авторы: Petriev V.M.1,2, Tishchenko V.K.1,2, Stepchenkova E.D.1,2, Zavestovskaya I.N.2,3, Shegai P.V.1, Ivanov S.A.1, Karpin A.D.1
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Учреждения:
- Tsyb Medical Radiological Research Center
- National Research Nuclear University “MEPhI”
- Lebedev Physical Institute
- Выпуск: Том 46, № 10 (2019)
- Страницы: 319-323
- Раздел: Article
- URL: https://journals.rcsi.science/1068-3356/article/view/229088
- DOI: https://doi.org/10.3103/S1068335619100051
- ID: 229088
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Аннотация
This paper concerns the study of the effect of the stable gallium carrier and its concentration on the biodistribution of a new osteotropic compound based on N,N,N′N′-ethylenediaminetetrakis (methylene phosphonic acid) and gallium-68 (68Ga-EDTMP). The studies are performed on intact Wistar rats. It is shown that the bone tissue activity increases as the carrier is added, whereas it decreases in internals and tissues. The carrier concentration has no significant effect on the 68Ga-EDTMP.
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Об авторах
V. Petriev
Tsyb Medical Radiological Research Center; National Research Nuclear University “MEPhI”
Автор, ответственный за переписку.
Email: petriev@mrrc.obninsk.ru
Россия, 4 Koroleva St., Obninsk, Kaluga oblast, 249036; 31 Kashirskoe Sh., Moscow, 115409
V. Tishchenko
Tsyb Medical Radiological Research Center; National Research Nuclear University “MEPhI”
Email: petriev@mrrc.obninsk.ru
Россия, 4 Koroleva St., Obninsk, Kaluga oblast, 249036; 31 Kashirskoe Sh., Moscow, 115409
E. Stepchenkova
Tsyb Medical Radiological Research Center; National Research Nuclear University “MEPhI”
Email: petriev@mrrc.obninsk.ru
Россия, 4 Koroleva St., Obninsk, Kaluga oblast, 249036; 31 Kashirskoe Sh., Moscow, 115409
I. Zavestovskaya
National Research Nuclear University “MEPhI”; Lebedev Physical Institute
Email: petriev@mrrc.obninsk.ru
Россия, 31 Kashirskoe Sh., Moscow, 115409; 53 Leninskii Pr., Moscow, 119991
P. Shegai
Tsyb Medical Radiological Research Center
Email: petriev@mrrc.obninsk.ru
Россия, 4 Koroleva St., Obninsk, Kaluga oblast, 249036
S. Ivanov
Tsyb Medical Radiological Research Center
Email: petriev@mrrc.obninsk.ru
Россия, 4 Koroleva St., Obninsk, Kaluga oblast, 249036
A. Karpin
Tsyb Medical Radiological Research Center
Email: petriev@mrrc.obninsk.ru
Россия, 4 Koroleva St., Obninsk, Kaluga oblast, 249036
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