Synthesis of thiazole-based substituted piperidinone oximes: Profiling of antioxidant and antimicrobial activity
- 作者: Naik N.1, Harini S.1, Kumar H.2, Rangaswamy J.1
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隶属关系:
- Department of Studies in Chemistry
- Department of Chemistry
- 期: 卷 43, 编号 2 (2017)
- 页面: 186-196
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228478
- DOI: https://doi.org/10.1134/S1068162017020042
- ID: 228478
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详细
The synthesis of novel thiazole-based piperidinone oximes and screening of their antioxidant and antimicrobial activity are described. The obtained results revealed that the electronic effects of active substituents at C-4 terminals of phenyl rings on either side of piperidinone skeleton, as well as at 2-hydrazinyl thiazole, played a major role in development of antioxidant and antimicrobial activity. Antioxidant activity seems to be based also on radical dissipating ability of the thiazole ring. The nucleophilic character of sulfur in thiazole and lipophilic nature of piperidinone skeleton substantially influenced the observed antimicrobial activity of thiazole-based piperidinone oximes. Among the synthesized compounds, 2,6-bis(4-hydroxy-3-methoxyphenyl)-1-methylpiperidin-4-one O-(2-(2-(4-hydroxy-3-methoxybenzylidene)hydrazinyl)thiazol-4-yl) oxime exhibited excellent antioxidant activity whereas compound 2,6-bis(4-chloro phenyl)-1-methylpiperidin-4-one O-(2-(2-(4-nitrobenzylidene)hydrazinyl)thiazol-4-yl)oxime emerged as an outstanding antimicrobial agent.
作者简介
Nagaraja Naik
Department of Studies in Chemistry
编辑信件的主要联系方式.
Email: drnaikchem@gmail.com
印度, Manasagangotri, Mysore, Karnataka, 570006
Salakatte Harini
Department of Studies in Chemistry
编辑信件的主要联系方式.
Email: st.harini988@gmail.com
印度, Manasagangotri, Mysore, Karnataka, 570006
Honnaiah Kumar
Department of Chemistry
Email: drnaikchem@gmail.com
美国, Minneapolis, MN, 55455
Javarappa Rangaswamy
Department of Studies in Chemistry
Email: drnaikchem@gmail.com
印度, Manasagangotri, Mysore, Karnataka, 570006