Synthesis of thiazole-based substituted piperidinone oximes: Profiling of antioxidant and antimicrobial activity
- Авторы: Naik N.1, Harini S.1, Kumar H.2, Rangaswamy J.1
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Учреждения:
- Department of Studies in Chemistry
- Department of Chemistry
- Выпуск: Том 43, № 2 (2017)
- Страницы: 186-196
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228478
- DOI: https://doi.org/10.1134/S1068162017020042
- ID: 228478
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Аннотация
The synthesis of novel thiazole-based piperidinone oximes and screening of their antioxidant and antimicrobial activity are described. The obtained results revealed that the electronic effects of active substituents at C-4 terminals of phenyl rings on either side of piperidinone skeleton, as well as at 2-hydrazinyl thiazole, played a major role in development of antioxidant and antimicrobial activity. Antioxidant activity seems to be based also on radical dissipating ability of the thiazole ring. The nucleophilic character of sulfur in thiazole and lipophilic nature of piperidinone skeleton substantially influenced the observed antimicrobial activity of thiazole-based piperidinone oximes. Among the synthesized compounds, 2,6-bis(4-hydroxy-3-methoxyphenyl)-1-methylpiperidin-4-one O-(2-(2-(4-hydroxy-3-methoxybenzylidene)hydrazinyl)thiazol-4-yl) oxime exhibited excellent antioxidant activity whereas compound 2,6-bis(4-chloro phenyl)-1-methylpiperidin-4-one O-(2-(2-(4-nitrobenzylidene)hydrazinyl)thiazol-4-yl)oxime emerged as an outstanding antimicrobial agent.
Об авторах
Nagaraja Naik
Department of Studies in Chemistry
Автор, ответственный за переписку.
Email: drnaikchem@gmail.com
Индия, Manasagangotri, Mysore, Karnataka, 570006
Salakatte Harini
Department of Studies in Chemistry
Автор, ответственный за переписку.
Email: st.harini988@gmail.com
Индия, Manasagangotri, Mysore, Karnataka, 570006
Honnaiah Kumar
Department of Chemistry
Email: drnaikchem@gmail.com
США, Minneapolis, MN, 55455
Javarappa Rangaswamy
Department of Studies in Chemistry
Email: drnaikchem@gmail.com
Индия, Manasagangotri, Mysore, Karnataka, 570006