Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase
- 作者: Khomutov M.1, Simonian A.1, Weisell J.2, Vepsalainen J.2, Kochetkov S.1, Khomutov A.1
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隶属关系:
- Engelhardt Institute of Molecular Biology
- School of Pharmacy
- 期: 卷 42, 编号 4 (2016)
- 页面: 415-422
- 栏目: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228027
- DOI: https://doi.org/10.1134/S1068162016040099
- ID: 228027
如何引用文章
详细
Earlier unknown hydroxylamine-containing analogues of 1-guanidino-7-aminohepane (GC7) containing the free aminooxy group (1-aminooxy-6-guanidinohexane), bis-guanyl derivatives of 1-aminooxy-6-aminohexane, and 1-aminooxy-5-aminopentane, and mono-guanidinooxy analogue (1-guanidinooxy-6-aminohexane) were synthesized in high overall yields from commercially available 5-(Boc-amino)1-pentanol and 6-(Boc-amino)-1-hexanol. It was demonstrated that 1,3-di-Boc-2-(trifluoromethylsulfonyl)guanidine is able to specifically amidinate the amino group in the presence of the free aminooxy group. The application of newly synthesized GC7 analogues for the investigation of the peculiarities of their interaction with the active site of deoxyhypusine synthase was discussed.
作者简介
M. Khomutov
Engelhardt Institute of Molecular Biology
Email: alexkhom@list.ru
俄罗斯联邦, ul. Vavilova 32, Moscow, 119991
A. Simonian
Engelhardt Institute of Molecular Biology
Email: alexkhom@list.ru
俄罗斯联邦, ul. Vavilova 32, Moscow, 119991
J. Weisell
School of Pharmacy
Email: alexkhom@list.ru
芬兰, Kuopio
J. Vepsalainen
School of Pharmacy
Email: alexkhom@list.ru
芬兰, Kuopio
S. Kochetkov
Engelhardt Institute of Molecular Biology
Email: alexkhom@list.ru
俄罗斯联邦, ul. Vavilova 32, Moscow, 119991
A. Khomutov
Engelhardt Institute of Molecular Biology
编辑信件的主要联系方式.
Email: alexkhom@list.ru
俄罗斯联邦, ul. Vavilova 32, Moscow, 119991