Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase
- Авторы: Khomutov M.1, Simonian A.1, Weisell J.2, Vepsalainen J.2, Kochetkov S.1, Khomutov A.1
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Учреждения:
- Engelhardt Institute of Molecular Biology
- School of Pharmacy
- Выпуск: Том 42, № 4 (2016)
- Страницы: 415-422
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228027
- DOI: https://doi.org/10.1134/S1068162016040099
- ID: 228027
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Аннотация
Earlier unknown hydroxylamine-containing analogues of 1-guanidino-7-aminohepane (GC7) containing the free aminooxy group (1-aminooxy-6-guanidinohexane), bis-guanyl derivatives of 1-aminooxy-6-aminohexane, and 1-aminooxy-5-aminopentane, and mono-guanidinooxy analogue (1-guanidinooxy-6-aminohexane) were synthesized in high overall yields from commercially available 5-(Boc-amino)1-pentanol and 6-(Boc-amino)-1-hexanol. It was demonstrated that 1,3-di-Boc-2-(trifluoromethylsulfonyl)guanidine is able to specifically amidinate the amino group in the presence of the free aminooxy group. The application of newly synthesized GC7 analogues for the investigation of the peculiarities of their interaction with the active site of deoxyhypusine synthase was discussed.
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Об авторах
M. Khomutov
Engelhardt Institute of Molecular Biology
Email: alexkhom@list.ru
Россия, ul. Vavilova 32, Moscow, 119991
A. Simonian
Engelhardt Institute of Molecular Biology
Email: alexkhom@list.ru
Россия, ul. Vavilova 32, Moscow, 119991
J. Weisell
School of Pharmacy
Email: alexkhom@list.ru
Финляндия, Kuopio
J. Vepsalainen
School of Pharmacy
Email: alexkhom@list.ru
Финляндия, Kuopio
S. Kochetkov
Engelhardt Institute of Molecular Biology
Email: alexkhom@list.ru
Россия, ul. Vavilova 32, Moscow, 119991
A. Khomutov
Engelhardt Institute of Molecular Biology
Автор, ответственный за переписку.
Email: alexkhom@list.ru
Россия, ul. Vavilova 32, Moscow, 119991