Human Nicotinic Acetylcholine Receptors: Part I—Structure, Function, and Role in Neuromuscular Transmission and CNS Functioning
- Авторы: Kulbatskii D.1,2, Bychkov M.2, Lyukmanova E.1,2
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Учреждения:
- Moscow State University
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
- Выпуск: Том 44, № 6 (2018)
- Страницы: 595-607
- Раздел: Review Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229037
- DOI: https://doi.org/10.1134/S1068162018060043
- ID: 229037
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Аннотация
Nicotinic acetylcholine receptors (nAChRs) are the ligand-gated ion channels important for intercellular signaling. These receptors are abundant in neuromuscular junctions, presynaptic and postsynaptic neuronal membranes in the central and peripheral nervous systems. The nAChR dysfunction is associated with a number of neurodegenerative and muscular diseases. The actual information on the structure and function of these receptors is reviewed in this article.
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Об авторах
D. Kulbatskii
Moscow State University; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina-lyukmanova@yandex.ru
Россия, Moscow, 119234; Moscow, 117997
M. Bychkov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina-lyukmanova@yandex.ru
Россия, Moscow, 117997
E. Lyukmanova
Moscow State University; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Автор, ответственный за переписку.
Email: ekaterina-lyukmanova@yandex.ru
Россия, Moscow, 119234; Moscow, 117997