Human Nicotinic Acetylcholine Receptors: Part I—Structure, Function, and Role in Neuromuscular Transmission and CNS Functioning
- Autores: Kulbatskii D.1,2, Bychkov M.2, Lyukmanova E.1,2
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Afiliações:
- Moscow State University
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
- Edição: Volume 44, Nº 6 (2018)
- Páginas: 595-607
- Seção: Review Article
- URL: https://journals.rcsi.science/1068-1620/article/view/229037
- DOI: https://doi.org/10.1134/S1068162018060043
- ID: 229037
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Resumo
Nicotinic acetylcholine receptors (nAChRs) are the ligand-gated ion channels important for intercellular signaling. These receptors are abundant in neuromuscular junctions, presynaptic and postsynaptic neuronal membranes in the central and peripheral nervous systems. The nAChR dysfunction is associated with a number of neurodegenerative and muscular diseases. The actual information on the structure and function of these receptors is reviewed in this article.
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Sobre autores
D. Kulbatskii
Moscow State University; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina-lyukmanova@yandex.ru
Rússia, Moscow, 119234; Moscow, 117997
M. Bychkov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Email: ekaterina-lyukmanova@yandex.ru
Rússia, Moscow, 117997
E. Lyukmanova
Moscow State University; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
Autor responsável pela correspondência
Email: ekaterina-lyukmanova@yandex.ru
Rússia, Moscow, 119234; Moscow, 117997