Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters
- Авторы: Fayrushina A.1, Baltina L.1, Baltina L.1, Konovalova N.2, Petrova P.2, Eropkin M.2
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Учреждения:
- Ufa Institute of Chemistry
- Research Institute of Influenza
- Выпуск: Том 43, № 4 (2017)
- Страницы: 456-462
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228618
- DOI: https://doi.org/10.1134/S1068162017040045
- ID: 228618
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Аннотация
Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of N-hydroxybenzotriazole or N-hydroxysuccinimide with N,N′-dicyclohexylcarbodiimide. GA conjugate with D-Trp ethyl ester exhibited antiviral activity against influenza viruses A/H3N2, A/H1N1/pdm09, A/H5N1, B (SI > 10–29), and HRSV (SI > 25). GA conjugate with D-Trp methyl ester inhibited influenza virus A/H1N1/pdm09 (SI > 30).
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Об авторах
A. Fayrushina
Ufa Institute of Chemistry
Email: baltina@anrb.ru
Россия, Ufa, 450054
L. Baltina
Ufa Institute of Chemistry
Email: baltina@anrb.ru
Россия, Ufa, 450054
L. Baltina
Ufa Institute of Chemistry
Автор, ответственный за переписку.
Email: baltina@anrb.ru
Россия, Ufa, 450054
N. Konovalova
Research Institute of Influenza
Email: baltina@anrb.ru
Россия, St. Petersburg, 197376
P. Petrova
Research Institute of Influenza
Email: baltina@anrb.ru
Россия, St. Petersburg, 197376
M. Eropkin
Research Institute of Influenza
Email: baltina@anrb.ru
Россия, St. Petersburg, 197376