New dipeptidyl peptidase 4 inhibitors among adamantane derivatives
- Авторы: Spasov A.A.1, Vasil’ev P.M.1, Babkov D.A.1, Prokhorova T.Y.1, Sturova E.A.1, Klimochkin Y.N.2, Leonova M.V.2, Baimuratov M.R.2
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Учреждения:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Samara State Technical University, Ministry of Education and Science of the Russian Federation
- Выпуск: Том 43, № 4 (2017)
- Страницы: 449-455
- Раздел: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228611
- DOI: https://doi.org/10.1134/S1068162017040124
- ID: 228611
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Аннотация
Fifteen adamantane derivatives were synthesized. Preliminary evaluation of their potential as dipeptidyl peptidase 4 (DPP-4) inhibitors was performed in silico by the Microcosm informational technology, PASS system, and docking in AutoDock Vina. The DPP-4 inhibition was studied in vitro. The selectivity of action of the most active compounds was studied by the direct inhibition of human plasma DPP-4 and recombinant human DPP-8. The highest activity was found for the compounds containing a nitrogen atom in the β-position of the side chain, namely, derivatives of adamantane carboxylic acid and N-(3-adamantyl-allyl) thiourea. We demonstrated that the most active compound of the series, 3,5-dimethyladamantane 1-carboxamide, was a selective DPP-4 inhibitor with IC50 53.94 μM.
Об авторах
A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: orgchem@samgtu.ru
Россия, Volgograd
P. Vasil’ev
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: orgchem@samgtu.ru
Россия, Volgograd
D. Babkov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: orgchem@samgtu.ru
Россия, Volgograd
T. Prokhorova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: orgchem@samgtu.ru
Россия, Volgograd
E. Sturova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: orgchem@samgtu.ru
Россия, Volgograd
Yu. Klimochkin
Samara State Technical University, Ministry of Education and Science of the Russian Federation
Автор, ответственный за переписку.
Email: orgchem@samgtu.ru
Россия, Samara, 443100
M. Leonova
Samara State Technical University, Ministry of Education and Science of the Russian Federation
Email: orgchem@samgtu.ru
Россия, Samara, 443100
M. Baimuratov
Samara State Technical University, Ministry of Education and Science of the Russian Federation
Email: orgchem@samgtu.ru
Россия, Samara, 443100
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