Synthesis and Cytotoxicity of Indole Derivatives of Betulin, Erythrodiol, and Uvaol


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has been found that 2,3-indolouvaol and 2,3-indolo-28-cyanoethoxybetulin exhibit antitumor activity in vitro toward NCI-H522 lung cancer (–12.65%) and COLO 205 colon cancer cells (–42.78%), respectively. The activity of 2,3-indolooleanolic and 2,3-indolobetulinic acids toward 19 and 9 cell lines of six and four human cancers, respectively, has been revealed. Indole-fused triterpenoids have been shown to hold promise as objects in the search for novel antitumor agents.

Авторлар туралы

E. Khusnutdinova

Institute of Chemistry

Хат алмасуға жауапты Автор.
Email: ElmaH@inbox.ru
Ресей, Ufa, 450054

A. Petrova

Bashkir State University

Email: ElmaH@inbox.ru
Ресей, Ufa, 450076

G. Apryshko

Blokhin Russian Oncological Research Center

Email: ElmaH@inbox.ru
Ресей, Moscow, 115478

O. Kukovinets

Bashkir State University

Email: ElmaH@inbox.ru
Ресей, Ufa, 450076

O. Kazakova

Institute of Chemistry

Email: ElmaH@inbox.ru
Ресей, Ufa, 450054

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

© Pleiades Publishing, Ltd., 2018