Synthesis and Study of Copper-Containing Polymers Based on Sulfated Arabinogalactan

Resumo

Synthesis of water-soluble copper-containing sulfates of arabinogalactan was carried out for the first time by the ion exchange method. Their composition and structure were studied by the methods of elemental and chemical analysis, X-ray spectral microanalysis, atomic force microscopy (AFM), infrared spectroscopy (FTIR), and electron paramagnetic resonance (EPR). According to the AFM data, the surface of copper-containing polymer films does not have inclusions and consists of homogeneous crystallites of a spherical and slightly elongated shape and transverse dimensions of about 100 nm. The composition of copper- containing polymers was studied by the chemical method and X-ray spectral microanalysis. The absence of nitrogen in the obtained polymer indicates the complete replacement of ammonium cations in the ammonium salt of AG sulfate with the copper cations. The IR spectrum of copper-containing AG sulfate is similar to that of the sodium salt of sulfated arabinogalactan. Superposition of two signals was observed in the EPR spectrum of copper-containing AG sulfate. One of them belongs to isolated Cu²⁺ ions; another, to associated Cu²⁺ ions in the salt-like compounds. The integral intensity of isolated Cu²⁺ ion signals (anisotropic signal) and associated ions (isotropic signal) depends on the copper content in the polymer. Water-soluble coppercontaining polymers of AG sulfates have prospects for their use in medicine.