Kunitz-type peptides of the sea anemone Heteractis crispa: Potential anti-inflammatory compounds
- Autores: Sintsova O.1, Pislyagin E.1, Gladkikh I.1, Monastyrnaya M.1, Menchinskaya E.1, Leychenko E.1,2, Aminin D.1, Kozlovskaya E.1
-
Afiliações:
- G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
- School of Natural Sciences
- Edição: Volume 43, Nº 1 (2017)
- Páginas: 91-97
- Seção: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228431
- DOI: https://doi.org/10.1134/S1068162016060121
- ID: 228431
Citar
Resumo
Antihistamine activity of recombinant peptides, Kunitz-type serine protease inhibitors of the sea anemone Heteractis crispa, was studied. It was shown that the peptides rHCGS1.19 and rHCGS1.36 at a concentration 10 μM inhibit an increase in the calcium ion concentration in macrophages elicited by histamine at 62.2 and 84.0%, respectively. The anti-inflammatory effect can be seen as the result of mediated reactions between peptides and proteases involved in these processes, as with the histamine H1-type receptor blocking.
Palavras-chave
Sobre autores
O. Sintsova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Rússia, pr. 100 let Vladivostoku 159, Vladivostok, 690022
E. Pislyagin
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Rússia, pr. 100 let Vladivostoku 159, Vladivostok, 690022
I. Gladkikh
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Rússia, pr. 100 let Vladivostoku 159, Vladivostok, 690022
M. Monastyrnaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Rússia, pr. 100 let Vladivostoku 159, Vladivostok, 690022
E. Menchinskaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Rússia, pr. 100 let Vladivostoku 159, Vladivostok, 690022
E. Leychenko
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch; School of Natural Sciences
Autor responsável pela correspondência
Email: 969844@gmail.com
Rússia, pr. 100 let Vladivostoku 159, Vladivostok, 690022; Vladivostok
D. Aminin
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Rússia, pr. 100 let Vladivostoku 159, Vladivostok, 690022
E. Kozlovskaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Rússia, pr. 100 let Vladivostoku 159, Vladivostok, 690022