Email this article Kunitz-type peptides of the sea anemone Heteractis crispa: Potential anti-inflammatory compounds
- Authors: Sintsova O.V.1, Pislyagin E.A.1, Gladkikh I.N.1, Monastyrnaya M.M.1, Menchinskaya E.S.1, Leychenko E.V.1,2, Aminin D.L.1, Kozlovskaya E.P.1
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Affiliations:
- G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
- School of Natural Sciences
- Issue: Vol 43, No 1 (2017)
- Pages: 91-97
- Section: Article
- URL: https://journals.rcsi.science/1068-1620/article/view/228431
- DOI: https://doi.org/10.1134/S1068162016060121
- ID: 228431
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Abstract
Antihistamine activity of recombinant peptides, Kunitz-type serine protease inhibitors of the sea anemone Heteractis crispa, was studied. It was shown that the peptides rHCGS1.19 and rHCGS1.36 at a concentration 10 μM inhibit an increase in the calcium ion concentration in macrophages elicited by histamine at 62.2 and 84.0%, respectively. The anti-inflammatory effect can be seen as the result of mediated reactions between peptides and proteases involved in these processes, as with the histamine H1-type receptor blocking.
About the authors
O. V. Sintsova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Russian Federation, pr. 100 let Vladivostoku 159, Vladivostok, 690022
E. A. Pislyagin
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Russian Federation, pr. 100 let Vladivostoku 159, Vladivostok, 690022
I. N. Gladkikh
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Russian Federation, pr. 100 let Vladivostoku 159, Vladivostok, 690022
M. M. Monastyrnaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Russian Federation, pr. 100 let Vladivostoku 159, Vladivostok, 690022
E. S. Menchinskaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Russian Federation, pr. 100 let Vladivostoku 159, Vladivostok, 690022
E. V. Leychenko
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch; School of Natural Sciences
Author for correspondence.
Email: 969844@gmail.com
Russian Federation, pr. 100 let Vladivostoku 159, Vladivostok, 690022; Vladivostok
D. L. Aminin
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Russian Federation, pr. 100 let Vladivostoku 159, Vladivostok, 690022
E. P. Kozlovskaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far Eastern Branch
Email: 969844@gmail.com
Russian Federation, pr. 100 let Vladivostoku 159, Vladivostok, 690022
